Role of transport systems in amino acid metabolism: leucine toxicity and the branched-chain amino acid transport systems
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چکیده
منابع مشابه
Bacterial Amino Acid Transport Systems
The roles of the cell membrane as both a permeability barrier to foreign substances and as a selective filter which admits nutrient molecules have been recognized as fundamentally important to animal physiology since the first decade of this century. It was not until the 1950's, however, that microbiologists recognized that bacteria possess membrane transport systems, distinct from their metabo...
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The transport of the branched-chain amino acids in Streptococcus agalactiae was characterized. Glucose-grown cells were able to utilize only glucose as an energy source for transport of L-leucine, whereas lactose-grown cells could utilize both glucose and lactose. It was determined from metabolic inhibitor studies that energy from glycolysis and substrate level phosphorylation was required for ...
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PURPOSE OF REVIEW The current review aims to provide an update on the recent biomedical interest in oncogenic branched-chain amino acid (BCAA) metabolism, and discusses the advantages of using BCAAs and expression of BCAA-related enzymes in the treatment and diagnosis of cancers. RECENT FINDINGS An accumulating body of evidence demonstrates that BCAAs are essential nutrients for cancer growth...
متن کاملBranched-Chain Amino Acid Transport in Escherichia coli
The transport of the branched-chain amino acids in Escherichia coli is mediated by at least three kinetically and genetically distinct active transport systems (6. 16, 18). There are two high-affinity, regulated, osmotic shock-sensitive systems (LIV -I and LS) and one low-affinity, constitutive, osmotic shock-resistant system (LJV-U) (8, 13). The LIV-I system is a general transport system for t...
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The three essential branched-chain amino acids (BCAAs), leucine, isoleucine and valine, share the first enzymatic steps in their metabolic pathways, including a reversible transamination followed by an irreversible oxidative decarboxylation to coenzyme-A derivatives. The respective oxidative pathways subsequently diverge and at the final steps yield acetyl- and/or propionyl-CoA that enter the K...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1977
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.129.3.1257-1265.1977